CD33 Antikörper (Biotin)
Kurzübersicht für CD33 Antikörper (Biotin) (ABIN94073)
Target
Alle CD33 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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                                            Verwendungszweck
- Anti-Hu CD33 Biotin
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                                            Spezifität
- The antibody HIM3-4 reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells, it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
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                                            Kreuzreaktivität (Details)
- Human, Non-Human Primates
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                                            Aufreinigung
- Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
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                                            Immunogen
- NFMY-9s human cell line
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                                            Isotyp
- IgG1
 
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                                            Applikationshinweise
- Flow cytometry: Recommended dilution: 1-12 μg/mL
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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    - 
                                            Konzentration
- 1 mg/mL
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                                            Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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                                            Konservierungsmittel
- Sodium azide
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                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            Handhabung
- 
                        Do not freeze. 
 Avoid prolonged exposure to light.
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                                            Lagerung
- 4 °C
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                                            Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
 
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    - 
                                            : "Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia."    in: Blood, Vol. 121, Issue 7, pp. e34-42, (2013)         (PubMed).        
 
 
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                                            : "Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia."    in: Blood, Vol. 121, Issue 7, pp. e34-42, (2013)         (PubMed).        
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    - CD33
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                                            Andere Bezeichnung
- CD33
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                                            Hintergrund
- CD33 Molecule,CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.,SIGLEC3, p67
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                                            Gen-ID
- 945
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                                            UniProt
- P20138
 Target
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