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Endoglin Antikörper

Dieses Anti-Endoglin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Endoglin in WB, FACS, IP und MS. Geeignet für Human und Ratte. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN93939

Kurzübersicht für Endoglin Antikörper (ABIN93939)

Target

Alle Endoglin (ENG) Antikörper anzeigen
Endoglin (ENG)

Reaktivität

  • 216
  • 71
  • 71
  • 20
  • 19
  • 16
  • 15
  • 3
  • 3
  • 3
  • 2
  • 1
Human, Ratte

Wirt

  • 133
  • 118
  • 21
  • 3
  • 2
  • 1
Maus

Klonalität

  • 151
  • 126
  • 1
Monoklonal

Konjugat

  • 119
  • 31
  • 28
  • 24
  • 15
  • 7
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Endoglin Antikörper ist unkonjugiert

Applikation

  • 165
  • 158
  • 90
  • 55
  • 48
  • 33
  • 29
  • 25
  • 25
  • 18
  • 13
  • 10
  • 7
  • 6
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Mass Spectrometry (MS)

Klon

MEM-226
  • Verwendungszweck

    Anti-Hu CD105 Purified

    Spezifität

    The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

    Kreuzreaktivität (Details)

    Human, Rat

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    Recombinant Vaccinia virus containing the human CD105 cDNA.

    Isotyp

    IgG2a
  • Applikationshinweise

    Flow cytometry: Recommended dilution: 1-5 μg/mL.
    Western blotting: Non-reducing conditions.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Schmidt, Achermann, Odermatt, Breymann, Mol, Genoni, Zund, Hoerstrup: "Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source." in: Circulation, Vol. 116, Issue 11 Suppl, pp. I64-70, (2007) (PubMed).

  • Target

    Endoglin (ENG)

    Andere Bezeichnung

    CD105

    Hintergrund

    Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG, HHT1, ORW1

    Gen-ID

    2022

    UniProt

    P17813
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