RANKL Antikörper

Produktnummer ABIN933803

Der Maus Monoklonal Anti-RANKL-Antikörper wurde für WB, ELISA und Inhibition validiert. Er ist geeignet, RANKL in Proben von Human zu detektieren.

Kurzübersicht für RANKL Antikörper (ABIN933803)

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RANKL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Blocking Antibody (Inhibition)

Klon: M912290

Produktdetails anti-RANKL Antikörper

Immunogen: RANKL antibody was raised in mouse using highly pure recombinant human sRANK ligand as the immunogen.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined byt he investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized from PBS.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Details zu RANKL

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Andere Bezeichnung: RANKL

Hintergrund: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Synonyms: Monoclonal RANKL antibody, Anti-RANKL antibody, soluble Receptor Activator of NFkB Ligand antibody, TNFSF11 antibody, TRANCE antibody, TNF-related activation-induced cytokine antibody, OPGL antibody, ODF antibody, Osteoclast differentiation factor antibody.

Molekulargewicht: 19.4 kDa (predicted detection band MW)

Pathways: NF-kappaB Signalweg