SYK Antikörper (AA 296-484)

Produktnummer ABIN931471

Dieser Maus Monoklonal Antikörper detektiert spezifisch SYK in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SYK Antikörper (AA 296-484) (ABIN931471)

Target: SYK (Spleen tyrosine Kinase (SYK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SYK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 8C1A3

Produktdetails anti-SYK Antikörper

Bindungsspezifität: AA 296-484

Immunogen: SYK antibody was raised in Mouse using a purified recombinant fragment of SYK(aa296-484) expressed in E. coli as the immunogen.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10,000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Details zu SYK

Target: SYK (Spleen tyrosine Kinase (SYK))

Andere Bezeichnung: SYK

Hintergrund: SYK is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions. Synonyms: Monoclonal SYK antibody, Anti-SYK antibody, Spleen tyrosine kinase antibody.

Pathways: Fc-epsilon Rezeptor Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling