Androgen Receptor Antikörper (AA 689-919)
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- Target Alle Androgen Receptor (AR) Antikörper anzeigen
- Androgen Receptor (AR)
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Bindungsspezifität
- AA 689-919
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Androgen Receptor Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Immunogen
- AR antibody was raised in Mouse using a purified recombinant fragment of AR(aa689-919) expressed in E. coli as the immunogen.
- Klon
- 1A9D12
- Isotyp
- IgG1
- Top Product
- Discover our top product AR Primärantikörper
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- Applikationshinweise
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ELISA: 1:10,000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. - Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 4 °C for short term storage. Store at -20 °C for long term storage.
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- Target
- Androgen Receptor (AR)
- Andere Bezeichnung
- AR (AR Produkte)
- Hintergrund
- AR functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. Synonyms: Monoclonal AR antibody, Anti-AR antibody, Androgen Receptor antibody.
- Pathways
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
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