IL7R Antikörper (Middle Region)

Produktnummer ABIN929122

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IL7R in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IL7R Antikörper (Middle Region) (ABIN929122)

Target: IL7R (Interleukin 7 Receptor (IL7R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL7R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IL7R Antikörper

Bindungsspezifität: Middle Region

Aufreinigung: Purified

Immunogen: IL7 R antibody was raised in rabbit using the middle region of IL7 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

IL7R Blocking Peptide, (ABIN938111), is also available for use as a blocking control in assays to test for specificity of this IL7R antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu IL7R

Target: IL7R (Interleukin 7 Receptor (IL7R))

Andere Bezeichnung: IL7R

Hintergrund: The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Synonyms: Polyclonal IL7R antibody, Anti-IL7R antibody, interleukin 7 receptor antibody, CD127 antibody, CDW127 antibody, IL-7R-alpha antibody, IL7RA antibody, ILRA antibody.

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size