FZR1 Antikörper (N-Term)

Produktnummer ABIN928538

Der Kaninchen Polyklonal Anti-FZR1-Antikörper wurde für WB validiert. Er ist geeignet, FZR1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für FZR1 Antikörper (N-Term) (ABIN928538)

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FZR1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Maus

Aufreinigung: Purified

Immunogen: Fzr1 antibody was raised in rabbit using the N terminal of Fzr1 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

Fzr1 Blocking Peptide, (ABIN5613680), is also available for use as a blocking control in assays to test for specificity of this Fzr1 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: Fzr1

Hintergrund: Fzr1 is the key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Fzr1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Synonyms: Polyclonal Fzr1 antibody, Anti-Fzr1 antibody, fizzy/cell division cycle 20 related 1, Drosophila antibody, AW108046 antibody, Cdh1 antibody, FZR antibody, FZR2 antibody, Fyr antibody, HCDH antibody, HCDH1 antibody.

Pathways: DNA Replication, Synthesis of DNA