REST Antikörper (Middle Region)

Produktnummer ABIN927729

Produktdetails anti-REST Antikörper

Target: REST (RE1-Silencing Transcription Factor (REST))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser REST Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus

Aufreinigung: Purified

Immunogen: Rest antibody was raised in rabbit using the middle region of Rest as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

Rest Blocking Peptide, catalog no. 33R-1402, is also available for use as a blocking control in assays to test for specificity of this Rest antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu REST

Target: REST (RE1-Silencing Transcription Factor (REST))

Andere Bezeichnung: Rest (REST Produkte)

Synonyme: NRSF antikoerper, XBR antikoerper, 2610008J04Rik antikoerper, AA407358 antikoerper, xbr antikoerper, nrsf antikoerper, rest antikoerper, resta antikoerper, REST antikoerper, RE1 silencing transcription factor antikoerper, RE1-silencing transcription factor antikoerper, RE1-silencing transcription factor S homeolog antikoerper, REST antikoerper, Rest antikoerper, rest.S antikoerper, rest antikoerper, LOC615792 antikoerper

Hintergrund: Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Synonyms: Polyclonal Rest antibody, Anti-Rest antibody, RE1-silencing transcription factor antibody, 2610008J04Rik antibody, AA407358 antibody, MGC150099 antibody, NRSF antibody.

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity