ACD Antikörper (C-Term)

Produktnummer ABIN927647

Der Kaninchen Polyklonal Anti-ACD-Antikörper wurde für WB validiert. Er ist geeignet, ACD in Proben von Maus zu detektieren.

Kurzübersicht für ACD Antikörper (C-Term) (ABIN927647)

Target: ACD (Adrenocortical Dysplasia Homolog (ACD))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ACD Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified

Immunogen: Acd antibody was raised in rabbit using the c terminal of Acd as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

Acd Blocking Peptide, (ABIN5611896), is also available for use as a blocking control in assays to test for specificity of this Acd antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu ACD

Target: ACD (Adrenocortical Dysplasia Homolog (ACD))

Andere Bezeichnung: Acd

Hintergrund: Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo. Synonyms: Polyclonal Acd antibody, Anti-Acd antibody, adrenocortical dysplasia antibody.

Pathways: Telomere Maintenance