KPNB1 Antikörper (N-Term)

Produktnummer ABIN926686

Produktdetails anti-KPNB1 Antikörper

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Purified

Immunogen: KPNB1 antibody was raised in rabbit using the N terminal of KPNB1 as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

KPNB1 Blocking Peptide, catalog no. 33R-2454, is also available for use as a blocking control in assays to test for specificity of this KPNB1 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu KPNB1

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Andere Bezeichnung: KPNB1 (KPNB1 Produkte)

Hintergrund: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Synonyms: Polyclonal KPNB1 antibody, Anti-KPNB1 antibody, karyopherin, importin beta 1 antibody, IMB1 antibody, IPO1 antibody, IPOB antibody, Impnb antibody, MGC2155 antibody, MGC2156 antibody, MGC2157 antibody, NTF97 antibody.

Pathways: Protein targeting to Nucleus