KPNB1 Antikörper (AA 9-214)

Produktnummer ABIN7156134

Produktdetails anti-KPNB1 Antikörper

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Bindungsspezifität: AA 9-214

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Importin subunit beta-1 protein (9-214AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KPNB1

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Andere Bezeichnung: KPNB1 (KPNB1 Produkte)

Synonyme: Afu1g15720 antikoerper, AO090005001133 antikoerper, imb1 antikoerper, impnb antikoerper, ipo1 antikoerper, ipob antikoerper, ntf97 antikoerper, IMB1 antikoerper, IPO1 antikoerper, IPOB antikoerper, Impnb antikoerper, NTF97 antikoerper, AA409963 antikoerper, importin beta-1 subunit antikoerper, Importin beta-1 subunit antikoerper, karyopherin (importin) beta 1 L homeolog antikoerper, importin beta 1 antikoerper, karyopherin subunit beta 1 antikoerper, karyopherin (importin) beta 1 antikoerper, AFUA_1G15720 antikoerper, AOR_1_1974174 antikoerper, Bm1_57540 antikoerper, PMAA_065830 antikoerper, AFLA_083750 antikoerper, TSTA_085870 antikoerper, BDBG_07509 antikoerper, MCYG_00039 antikoerper, kpnb1.L antikoerper, LOC100533387 antikoerper, KPNB1 antikoerper, Kpnb1 antikoerper

Hintergrund:

Background: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Aliases: IMB 1 antibody, IMB1 antibody, IMB1_HUMAN antibody, Impnb antibody, Importin 90 antibody, Importin beta 1 antibody, Importin beta 1 subunit antibody, Importin subunit beta-1 antibody, Importin-90 antibody, IPOB antibody, Karyopherin beta 1 antibody, Karyopherin beta 1 subunit antibody, Karyopherin subunit beta-1 antibody, KPNB 1 antibody, Kpnb1 antibody, MGC2155 antibody, MGC2156 antibody, MGC2157 antibody, NTF 97 antibody, NTF97 antibody, NTF97/Importin beta antibody, Nuclear factor P97 antibody, Pore targeting complex 97 kDa subunit antibody, PTAC97 antibody

UniProt: Q14974

Pathways: Protein targeting to Nucleus