PPP1R12A Antikörper (C-Term)

Produktnummer ABIN926675

Der Kaninchen Polyklonal Anti-PPP1R12A-Antikörper wurde für WB validiert. Er ist geeignet, PPP1R12A in Proben von Human zu detektieren.

Kurzübersicht für PPP1R12A Antikörper (C-Term) (ABIN926675)

Target: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP1R12A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PPP1R12A Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified

Immunogen: PPP1 R11 antibody was raised in rabbit using the C terminal of PPP1 11 as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

PPP1R12A Blocking Peptide, (ABIN5615508), is also available for use as a blocking control in assays to test for specificity of this PPP1R12A antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu PPP1R12A

Target: PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))

Andere Bezeichnung: PPP1R12A

Hintergrund: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Synonyms: Polyclonal PPP1R12A antibody, Anti-PPP1R12A antibody, protein phosphatase 1, regulatory, inhibitor subunit 12A antibody, MBS antibody, MGC133042 antibody, MYPT1 antibody.

Pathways: M Phase