MDM4-binding Protein Antikörper (N-Term)

Produktnummer ABIN926007

Dieses Anti-MDM4-binding Protein-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MDM4-binding Protein in WB. Geeignet für Human, Rind (Kuh) und Hund.

Kurzübersicht für MDM4-binding Protein Antikörper (N-Term) (ABIN926007)

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Reaktivität: Human, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MDM4-binding Protein Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MDM4-binding Protein Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Hund, Rind (Kuh)

Immunogen: MDM4 antibody was raised in rabbit using the N terminal of MDM4 as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

MDM4 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this MDM4 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu MDM4-binding Protein

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Andere Bezeichnung: MDM4

Hintergrund: MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Synonyms: Polyclonal MDM4 antibody, Anti-MDM4 antibody, Mdm4 p53 binding protein homolog, mouse antibody, DKFZp781B1423 antibody, MDMX antibody, MGC132766 antibody, MRP1 antibody.

Pathways: Zellzyklus