DFFA Antikörper (N-Term)

Produktnummer ABIN925765

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DFFA in WB. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für DFFA Antikörper (N-Term) (ABIN925765)

Target: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DFFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DFFA Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Ratte (Rattus)

Immunogen: DFFA antibody was raised in rabbit using the N terminal of DFFA as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 5 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

DFFA Blocking Peptide, (ABIN5613183), is also available for use as a blocking control in assays to test for specificity of this DFFA antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu DFFA

Target: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Andere Bezeichnung: DFFA

Hintergrund: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Synonyms: Polyclonal DFFA antibody, Anti-DFFA antibody, DNA fragmentation factor, 45kDa, alpha polypeptide antibody, DFF-45 antibody, DFF1 antibody, Ion ChannelAD antibody.

Pathways: Apoptose, Caspase Kaskade in der Apoptose