FAS Antikörper (FITC)

Produktnummer ABIN920646

Produktdetails anti-FAS Antikörper (FITC)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FAS Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC)

Spezifität: Reacts specifically with the human Fas antigen, although the epitope has not been mapped. Binds both the soluble and membrane-bound forms of Fas. Does not react with mouse or gibbon Fas. Recognizes activated T-cells and a subpopulation of B-cells. The cell-surface Fas antigen is a 48 kDa transmembrane protein that can mediate apoptosis/programmed cell death and belongs to the nerve growth factor (NGF)/tumor necrosis factor (TNF) receptor superfamily. The human Fas antigen is expressed in various human cells, including activated peripheral T and B lymphocytes, Various tumor cell lines, leukemic T cells, and myeloid cells. It is also differentially expressed on human thymocytes during thymic maturation.

Produktmerkmale: Mouse myeloma (P3.X63.Ag8.653) x immunized mouse (Balb/c) spleen cells.

Aufreinigung: Purified by protein A chromatography

Reinheit: > 95 % by SDS-PAGE.

Immunogen: Human B lymphoblast cell line SKW6.4 cell surface molecules

Klon: APO-1-1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on cryostat sections and on cytospin preparations. Not suitable for use on paraffin sections. Flow Cytometry: Use at 1:20 dilution (as determined on SKW6.4 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: FITC-labeled antibody in 1 ml PBS, pH 7.4 with 1% BSA and 0.02% NaN3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: Fas (FAS Produkte)

Synonyme: ALPS1A antikoerper, APO-1 antikoerper, APT1 antikoerper, CD95 antikoerper, FAS1 antikoerper, FASTM antikoerper, TNFRSF6 antikoerper, AI196731 antikoerper, APO1 antikoerper, TNFR6 antikoerper, Tnfrsf6 antikoerper, lpr antikoerper, Fas cell surface death receptor antikoerper, Fas (TNF receptor superfamily member 6) antikoerper, FAS antikoerper, Fas antikoerper, fas antikoerper

Hintergrund: Monoclonal antibody recognizing Fas protein, FITC-labeled for simplified flow cytometry procedures. Clone Apo-1-1 is an IgG1 isotype switch variant of the IgG3 clone APO-1-3 (Cat. No. MC-095).

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity