ErbB2/Her2 Antikörper

Produktnummer ABIN920575

Dieser Maus Monoklonal Antikörper detektiert spezifisch ErbB2/Her2 in WB, IHC (p), IP und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte und Affe. Es wurde in 6+ Publikationen zitiert.

Kurzübersicht für ErbB2/Her2 Antikörper (ABIN920575)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 3B5

Produktdetails anti-ErbB2/Her2 Antikörper

Produktmerkmale: Tumour marker

Aufreinigung: The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C/-20 °C

Referenzen für anti-ErbB2/Her2 Antikörper (ABIN920575)

Schwechheimer, Läufle, Schmahl, Knödlseder, Fischer, Höfler: "Expression of neu/c-erbB-2 in human brain tumors." in: Human pathology, Vol. 25, Issue 8, pp. 772-80, (1994) (PubMed).

Singleton, Niehans, Gu, Litz, Hagen, Qiu, Kiang, Strickler: "Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry." in: Human pathology, Vol. 23, Issue 10, pp. 1141-50, (1992) (PubMed).

De Potter, Quatacker, Maertens, Van Daele, Pauwels, Verhofstede, Eechaute, Roels: "The subcellular localization of the neu protein in human normal and neoplastic cells." in: International journal of cancer. Journal international du cancer, Vol. 44, Issue 6, pp. 969-74, (1990) (PubMed).

van Leeuwen, van de Vijver, Lomans, van Deemter, Jenster, Akiyama, Yamamoto, Nusse: "Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies." in: Oncogene, Vol. 5, Issue 4, pp. 497-503, (1990) (PubMed).

De Potter, Van Daele, Van de Vijver, Pauwels, Maertens, De Boever, Vandekerckhove, Roels: "The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues." in: Histopathology, Vol. 15, Issue 4, pp. 351-62, (1989) (PubMed).

van de Vijver, Peterse, Mooi, Wisman, Lomans, Dalesio, Nusse: "Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer." in: The New England journal of medicine, Vol. 319, Issue 19, pp. 1239-45, (1988) (PubMed).

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: Neu-Oncogen / C-Erb B2

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development