PHGDH Antikörper (AA 101-200) (Cy7)

Produktnummer ABIN910987

Produktdetails anti-PHGDH Antikörper (Cy7)

Target: PHGDH (phosphoglycerate Dehydrogenase (PHGDH))

Bindungsspezifität: AA 101-200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHGDH Antikörper ist konjugiert mit Cy7

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PHGDH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PHGDH

Target: PHGDH (phosphoglycerate Dehydrogenase (PHGDH))

Andere Bezeichnung: PHGDH (PHGDH Produkte)

Synonyme: fb38f06 antikoerper, zgc:65956 antikoerper, wu:fb38f06 antikoerper, embryo sac development arrest 9 antikoerper, F10M10.7 antikoerper, ECK2909 antikoerper, JW2880 antikoerper, 3-PGDH antikoerper, 3PGDH antikoerper, 4930479N23 antikoerper, A10 antikoerper, PGAD antikoerper, PGD antikoerper, PGDH antikoerper, SERA antikoerper, PDG antikoerper, phosphoglycerate dehydrogenase antikoerper, D-3-phosphoglycerate dehydrogenase antikoerper, 3-phosphoglycerate dehydrogenase antikoerper, phgdh antikoerper, EDA9 antikoerper, serA antikoerper, Sthe_2284 antikoerper, Dacet_1260 antikoerper, Mrub_0173 antikoerper, MMAH_RS07650 antikoerper, Arnit_0487 antikoerper, Ndas_0174 antikoerper, Mesil_2386 antikoerper, Slip_0010 antikoerper, Trad_0302 antikoerper, Acear_0027 antikoerper, Mahau_0665 antikoerper, MZHIL_RS05165 antikoerper, Mesop_1331 antikoerper, Thein_0855 antikoerper, Phgdh antikoerper, PHGDH antikoerper

Hintergrund:

Synonyms: NLS, PDG, PGD, NLS1, PGAD, PGDH, SERA, 3PGDH, 3-PGDH, PHGDHD, HEL-S-113, D-3-phosphoglycerate dehydrogenase, PHGDH, PGDH3

Background: The survival and development of central neurons require the supply of trophic factors by glial cells. The trophic actions of glial cells on Purkinje neurons are mediated by L-serine and glycine, which are glia-derived trophic factors synthesized by 3PGDH (1). 3PGDH protein is 544 amino acids in length. Two distinct mRNA transcripts that encode for 3PGDH protein in normal human tissues are dominant 2.1 kb mRNA, which is highly expressed in prostate, testis, ovary, brain, liver, kidney, and pancreas, and weakly expressed in thymus, colon, and heart, and 710 bp mRNA, which is highly expressed in heart and skeletal muscle (2). 3PGDH is regulated at the transcriptional level depending on tissue specificity and cellular proliferative status (2). 3PGDH protein is also highly expressed in adult and fetal brain tissues (3). 3PGDH protein plays an important role in the metabolism, development, and function of the central nervous system (3) and its deficiency is a treatable congential error (4-5) that impairs L-serine biosynthesis which is characterized by congenital microcephaly, psychomotor retardation, and seizures (3).

Gen-ID: 26227

UniProt: O43175

Pathways: Metabolism of Steroid Hormones and Vitamin D, Warburg Effekt