Neurofibromin 1 Antikörper (AA 2701-2839) (AbBy Fluor® 647)

Produktnummer ABIN908149

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Neurofibromin 1 in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für Neurofibromin 1 Antikörper (AA 2701-2839) (AbBy Fluor® 647) (ABIN908149)

Target: Neurofibromin 1 (NF1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurofibromin 1 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Neurofibromin 1 Antikörper (AbBy Fluor® 647)

Bindungsspezifität: AA 2701-2839

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Neurofibromin 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Andere Bezeichnung: NF1

Hintergrund:

Synonyms: Neurofibromin 1, DKFZp686J1293, FLJ21220, Neurofibromatosis Noonan syndrome, Neurofibromatosis related protein NF 1, Neurofibromatosis related protein NF1, neurofibromatosis type I, Neurofibromatosis-related protein NF-1, Neurofibromin 1, Neurofibromin truncated, Neurofibromin1, NF 1, NF, NF1, NF1_HUMAN, NFNS, Type 1 Neurofibromatosis, von Recklinghausen disease neurofibromin, von Recklinghausen disease related protein VRNF, VRNF, WATS, Watson disease related protein WSS, Watson syndrome, WSS.

Background: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008].

Gen-ID: 4763

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity