MAFA Antikörper (AbBy Fluor® 350)

Produktnummer ABIN905353

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAFA in WB und IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für MAFA Antikörper (AbBy Fluor® 350) (ABIN905353)

Target: MAFA (Transcription Factor MafA (MAFA))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAFA Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-MAFA Antikörper (AbBy Fluor® 350)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Mafa

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MAFA

Target: MAFA (Transcription Factor MafA (MAFA))

Andere Bezeichnung: Mafa

Hintergrund:

Synonyms: Mafa homolog, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A,Pancreatic beta-cell-specic transcriptional activator,avianV-maf musculoaponeurotic fibrosarcoma oncogene homolog A, MAFA_MOUSE.

Background: Insulin gene expression is regulated by several islet-enriched transcription factors. However, MAFA is the only beta cell-specific activator. MAFA selectively induces endogenous insulin transcription in non-beta cells. MAFA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MAFA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.

Gen-ID: 389692

Pathways: Hormone Transport