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mGluR1 + mGluR5 Antikörper (Glutamate Receptor, Metabotropic 5/1) AA 651-750 (Alexa Fluor 647) Primary Antibody

mGluR1/5 Reaktivität: Human, Maus, Ratte FACS, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 647
Pubmed (1 reference)
Produktnummer ABIN899769
$438.15
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 11 bis 16 Werktagen
  • Target See all mGluR1 + mGluR5 (mGluR1/5) products
    mGluR1 + mGluR5 (mGluR1/5)
    Bindungsspezifität
    • 15
    • 5
    • 3
    • 3
    • 1
    AA 651-750
    Reaktivität
    • 24
    • 21
    • 21
    • 2
    Human, Maus, Ratte
    Wirt
    • 18
    • 8
    Kaninchen
    Klonalität
    • 18
    • 8
    Polyklonal
    Konjugat
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser mGluR1 + mGluR5 Antikörper ist konjugiert mit Alexa Fluor 647
    Applikation
    • 14
    • 13
    • 12
    • 12
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Dog,Cow,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GRM1
    Isotyp
    IgG
  • Applikationshinweise
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Haltbarkeit
    12 months
  • Atluri, Kanthikeel, Reddy, Yndart, Nair: "Human synaptic plasticity gene expression profile and dendritic spine density changes in HIV-infected human CNS cells: role in HIV-associated neurocognitive disorders (HAND)." in: PLoS ONE, Vol. 8, Issue 4, pp. e61399, (2013) (PubMed).

  • Target
    mGluR1 + mGluR5 (mGluR1/5)
    Abstract
    mGluR1/5 Produkte
    Hintergrund

    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms, some of which may have distinct functions. [provided by RefSeq].

    Subcellular location: Cell membrane

    Synonyms: glutamate receptor metabotropic 1, Glutamate Receptor Metabotropic 1,Metabotropic glutamate receptor 1, mGluR1,MGLUR1, GRM1_HUMAN, MGLUR5, mGlur5, GRM5, GRM5_HUMAN.

    Gen-ID
    2911, 2915
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