FKBP8 Antikörper (AA 255-350) (HRP)

Produktnummer ABIN897298

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FKBP8 in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für FKBP8 Antikörper (AA 255-350) (HRP) (ABIN897298)

Target: FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FKBP8 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-FKBP8 Antikörper (HRP)

Bindungsspezifität: AA 255-350

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FKBP38

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FKBP8

Target: FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))

Andere Bezeichnung: FKBP38

Hintergrund:

Synonyms: 38 kDa FK 506 binding protein homolog, 38 kDa FK506-binding protein, 38 kDa FKBP, 38 kDa antibody FK506 binding protein 8, FK506 binding protein 8, 38 kDa, FK506 binding protein, 38 kDa, FK506-binding protein 8, FKBP 38, FKBP-38, FKBP-8, FKBP8, FKBP8_HUMAN, FKBPR38, hFKBP38, Peptidyl-prolyl cis-trans isomerase FKBP8, PPIase FKBP8, Rotamase, Sam11.

Background: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27, may negatively regulate ZFYVE27 phosphorylation.Tissue specificity: Widely expressed. Highest levels seen in the brain.

Gen-ID: 23770

Pathways: Autophagie