Filamin A Antikörper (AA 1851-1960) (AbBy Fluor® 488)

Produktnummer ABIN897272

Der Kaninchen Polyklonal Anti-Filamin A-Antikörper wurde für WB, IF (p) und IF (cc) validiert. Er ist geeignet, Filamin A in Proben von Human zu detektieren.

Kurzübersicht für Filamin A Antikörper (AA 1851-1960) (AbBy Fluor® 488) (ABIN897272)

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Filamin A Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-Filamin A Antikörper (AbBy Fluor® 488)

Bindungsspezifität: AA 1851-1960

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Filamin A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Andere Bezeichnung: Filamin A

Hintergrund:

Synonyms: ABP 280, ABP 280 like protein, ABP-280, ABP280A, ABPA, Actin binding like protein, Actin binding protein 280, Actin-binding protein 280, Alpha filamin, Alpha-filamin, APBX, cb967, Dilp2, Endothelial actin binding protein, Endothelial actin-binding protein, Filamin 1, Filamin A alpha actin binding protein 280, Filamin A, Filamin-1, Filamin-A, FLN, FLN-A, FLN1, FLNA, FLNA_HUMAN, FMD, MNS, NHBP, Non muscle filamin, Non-muscle filamin, OPD, OPD1, OPD2.

Background: Caldesmon, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins. Both muscular (CDh) and non-muscular (CDl) forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and Myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CDl is widely expressed in non-muscle tissues and cells. Filamin 1, which is ubiquitously expressed and exists as a homodimer, functions to crosslink Actin to filaments. Nebulin is a large filamentous protein specific to muscle tissue that may function as a ruler for filament length. Several isoforms of Nebulin are produced by alternative exon usage. Villin is Ca2+-regulated and is the major structural component of the brush border of absorptive cells.

Gen-ID: 2316

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location