CPB2 Antikörper (AA 131-230) (AbBy Fluor® 647)

Produktnummer ABIN892103

Der Kaninchen Polyklonal Anti-CPB2-Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, CPB2 in Proben von Human zu detektieren.

Kurzübersicht für CPB2 Antikörper (AA 131-230) (AbBy Fluor® 647) (ABIN892103)

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CPB2 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-CPB2 Antikörper (AbBy Fluor® 647)

Bindungsspezifität: AA 131-230

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CPB2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CPB2

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Andere Bezeichnung: CPB2

Hintergrund:

Synonyms: Carboxypeptidase B like protein, Carboxypeptidase U, CarboxypeptidaseB2, Carboxypeptidase B2, CarboxypeptidaseU, CP B2, CPB 2, CPB2, CPU, PCPB, Plasma carboxypeptidase B, Plasma carboxypeptidase B2, Procarboxypeptidase B, Procarboxypeptidase R, Procarboxypeptidase U, TAFI, Thrombin activable fibrinolysis inhibitor, Thrombin activatable fibrinolysis inhibitor.

Background: This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues, pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5-10 μg/mL. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.

Gen-ID: 1361

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis