SIRPA Antikörper (C-Term) (PE-Cy5.5)

Produktnummer ABIN888881

Der Kaninchen Polyklonal Anti-SIRPA-Antikörper wurde für FACS validiert. Er ist geeignet, SIRPA in Proben von Human, Ratte, Maus, Rind (Kuh), Schwein, Pferd und Hund zu detektieren.

Kurzübersicht für SIRPA Antikörper (C-Term) (PE-Cy5.5) (ABIN888881)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Schwein, Pferd, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRPA Antikörper ist konjugiert mit PE-Cy5.5

Applikation: Flow Cytometry (FACS)

Produktdetails anti-SIRPA Antikörper (PE-Cy5.5)

Bindungsspezifität: C-Term

Spezifität: Excitation / Emission Wavelengths: 480,565,675nm/694nm

Kreuzreaktivität: Ratte (Rattus), Maus, Kaninchen, Schwein, Rind (Kuh), Pferd

Aufreinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Immunogen: KLH conjugated synthetic peptide derived from human CD172a

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: SIRP Alpha

Hintergrund: Protein tyrosine phosphatases (PTPases) SHP1 and SHP2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1),SHPS1 , MyD1, BIT and p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.
Synonym: Signal regulatory protein alpha type 1, BIT, Brain Ig like molecule with tyrosine based activation motifs, Brain immunoglobulin like molecule with tyrosine based activation motifs, CD172 antigen like family member A, CD172a, CD172a antigen, Inhibitory receptor SHPS1, Macrophage fusion receptor, MFR, MYD 1, Myd 1, MYD1, p84,Protein tyrosine phosphatase non receptor type substrate 1, PTPNS1, SHP Substrate 1, SHPS1, Signal regulatory protein alpha 2, Signal regulatory protein alpha 3, Signal regulatory protein alpha, Signal Regulatory Protein Alpha Type 1, Signal regulatory protein alpha type 2, SIRP, SIRPA, SIRPalpha, SIRPalpha1, SIRPalpha2, SIRPalpha3, Tyrosine phosphatase SHP substrate 1, Tyrosine protein phosphatase non receptor type substrate 1, Tyrosine protein phosphatase non receptor type substrate.

Molekulargewicht: 56kDa

Gen-ID: 140885