c-FOS Antikörper (pSer32) (AbBy Fluor® 555)

Produktnummer ABIN875519

Der Kaninchen Polyklonal Anti-c-FOS-Antikörper wurde für WB, IF (cc), IF (p) und FACS validiert. Er ist geeignet, c-FOS in Proben von Human und Ratte zu detektieren.

Kurzübersicht für c-FOS Antikörper (pSer32) (AbBy Fluor® 555) (ABIN875519)

Target: c-FOS (c-Fos) (c-Fos)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser c-FOS Antikörper ist konjugiert mit AbBy Fluor® 555

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)

Produktdetails anti-c-FOS Antikörper (AbBy Fluor® 555)

Bindungsspezifität: pSer32

Kreuzreaktivität: Human, Ratte

Homologie: Mouse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Ser32

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu c-FOS

Target: c-FOS (c-Fos) (c-Fos)

Andere Bezeichnung: c-Fos

Hintergrund:

Synonyms: p55, AP-1, C-FOS, Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, FOS, G0S7

Background: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Gen-ID: 2353

UniProt: P01100

Pathways: S100 Proteine