Crossover junction endonuclease EME1 (EME1) (AA 412-500) Antikörper

Produktnummer ABIN873042

Dieses Anti--Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von in WB, ELISA, IHC (fro), IHC (p), IF (cc) und IF (p). Geeignet für Human.

Kurzübersicht für Crossover junction endonuclease EME1 (EME1) (AA 412-500) Antikörper (ABIN873042)

Target: Crossover junction endonuclease EME1 (EME1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails

Bindungsspezifität: AA 412-500

Homologie: Human,Mouse,Rat,Dog,Sheep,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EME1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Crossover junction endonuclease EME1 (EME1)

Andere Bezeichnung: EME1

Hintergrund:

Synonyms: Crossover junction endonuclease EME1, Eme1 essential meiotic endonuclease 1 homolog 1 S. pombe, EME1, S. pombe, homolog of, 1, essential meiotic endonuclease 1 homolog 1 S pombe, Essential Meiotic Endonuclease 1 Homolog 1, essential meiotic endonuclease 1 homolog 2, Essential meiotic endonuclease 1, S. pombe, homolog of, 1, hMMS4, homolog of yeast EME1 endonuclease, MMS4, MMS4 homolog, MMS4L, EME1_HUMAN.

Background: EME1 complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein (MUS81) to form an endonuclease complex which cleaves branched DNA structures, especially those arising during stalled DNA replication. The protein may be involved in repairing DNA damage and in maintaining genomic stability. It interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. Alternative splicing results in multiple transcript variants.

Gen-ID: 146956