MAP2K5 Antikörper (AA 311-315)

Produktnummer ABIN871696

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MAP2K5 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für MAP2K5 Antikörper (AA 311-315) (ABIN871696)

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAP2K5 Antikörper

Bindungsspezifität: AA 311-315

Spezifität: The antibody detects endogenous level of total MEK5 protein.

Aufreinigung: Affinity purified

Immunogen: Peptide sequence around AA 311-315 (K-T-Y-V-G ) derived from Rat MEK5. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Andere Bezeichnung: MEK5

Hintergrund: A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Molekulargewicht: 49 kDa

Gen-ID: 29568

NCBI Accession: NP_001029

UniProt: Q62862

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung