FAS Antikörper (AA 323-327)

Produktnummer ABIN871645

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FAS in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für FAS Antikörper (AA 323-327) (ABIN871645)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FAS Antikörper

Bindungsspezifität: AA 323-327

Spezifität: The antibody detects endogenous level of total Fas protein.

Aufreinigung: Affinity purified

Immunogen: Peptide sequence around AA 323-327 (E-N-S-N-F) derived from human Fas . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: Fas

Hintergrund: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Molekulargewicht: 40-50 kDa

Gen-ID: 355

NCBI Accession: NP_000034

UniProt: P25445

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity