B-Cell Linker Antikörper

Produktnummer ABIN865398

Dieses Anti-B-Cell Linker-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von B-Cell Linker in WB, ELISA, IHC, FACS und IF. Geeignet für Human und Maus.

Kurzübersicht für B-Cell Linker Antikörper (ABIN865398)

Target: B-Cell Linker (BLNK)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser B-Cell Linker Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: 5G9

Produktdetails anti-B-Cell Linker Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human BLNK expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100g/100l

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu B-Cell Linker

Target: B-Cell Linker (BLNK)

Andere Bezeichnung: BLNK

Hintergrund: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Synonyms: AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051

Molekulargewicht: 68kDa

Gen-ID: 29760

Pathways: BCR Signaling