MAP2K5 Antikörper (pSer137)

Produktnummer ABIN801978

Produktdetails anti-MAP2K5 Antikörper

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Bindungsspezifität: pSer137

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Kreuzreaktivität: Human, Ratte

Homologie: Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human MEK5 around the phosphorylation site of Ser137

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Andere Bezeichnung: MEK5 (MAP2K5 Produkte)

Synonyme: Mek5 antikoerper, HsT17454 antikoerper, MAPKK5 antikoerper, MEK5 antikoerper, PRKMK5 antikoerper, AI324775 antikoerper, AI428457 antikoerper, Mapkk5 antikoerper, Prkmk5 antikoerper, fb73f02 antikoerper, wu:fb73f02 antikoerper, zgc:172137 antikoerper, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 antikoerper, ATMAP2K_ALPHA antikoerper, ATMEK5 antikoerper, ATMKK5 antikoerper, MAP KINASE KINASE 5 antikoerper, MAP kinase kinase 5 antikoerper, MAP2K_A antikoerper, mitogen activated protein kinase kinase 5 antikoerper, mitogen-activated protein kinase kinase 5 antikoerper, mitogen-activated protein kinase kinase 5 L homeolog antikoerper, MAP kinase kinase 5 antikoerper, Map2k5 antikoerper, MAP2K5 antikoerper, map2k5 antikoerper, map2k5.L antikoerper, MKK5 antikoerper

Hintergrund:

Synonyms: MAP2K5phospho S129, Dual specicity mitogen activated protein kinase kinase 5, MAP kinase kinase 5, MAP kinase kinase MEK5b, MAP2K5, MAPK/ERK kinase 5, MAPKK5, PRKMK5, EC 2.7.12.2.

Background: MEK5 is a dual specificity protein kinase belonging to thr Ser/Thr protein kinase family, (MAP kinase kinase family). It is activated by phosphorylation on Ser/Thr by MAP kinase kinases and interacts specifically with ERK5, and not with another MAP kinase like P38. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). It is not phosphorylated by RAFA, RAFB or RAFC and it may interact with GTPases such as CDC42. The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. MEK5 is expressed in many adult tissues and is most abundant in heart and skeletal muscle.

Gen-ID: 5607

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung