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Seladin 1 Antikörper (Cy5.5)

Der Kaninchen Polyklonal Anti-Seladin 1-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, Seladin 1 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN801368

Kurzübersicht für Seladin 1 Antikörper (Cy5.5) (ABIN801368)

Target

Alle Seladin 1 (DHCR24) Antikörper anzeigen
Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))

Reaktivität

  • 43
  • 35
  • 26
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 41
  • 2
Kaninchen

Klonalität

  • 43
Polyklonal

Konjugat

  • 18
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Seladin 1 Antikörper ist konjugiert mit Cy5.5

Applikation

  • 31
  • 12
  • 12
  • 5
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Kreuzreaktivität

    Maus, Schwein, Ratte

    Homologie

    Human,Dog,Cow,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Seladin 1

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))

    Andere Bezeichnung

    Seladin 1

    Hintergrund

    Synonyms: Seladin1, Seladin-1, DHCR24, 24 dehydrocholesterol reductase, 3-beta-hydroxysterol delta-24-reductase, DCE, Desmosterol to cholesterol enzyme, Diminuto dwarf1 homolog, SELADIN1, Selective AD indicator 1, Selective Alzheimer's Disease Indicator 1.

    Background: Seladin 1 is highly expressed in brain, adrenal tissues and adrenal tumours, where this enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates such as desmosterol, during cholesterol biosynthesis. In addition, Seladin 1 has an anti-apoptotic function by reducing caspase 3 activity during oxidative stress-induced apoptosis and protecting cells against amyloid-beta peptide-induced apoptosis. Several studies have identified a reduction in expression levels of this enzyme in brain regions affected by Alzheimer's disease (hippocampus and the subventricular zone).

    Gen-ID

    1718
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