PDGFRA Antikörper (AA 1035-1053)

Produktnummer ABIN784591

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PDGFRA in WB, IHC (p) und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Huhn und Xenopus laevis.

Kurzübersicht für PDGFRA Antikörper (AA 1035-1053) (ABIN784591)

Target: PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

Reaktivität: Human, Maus, Ratte, Huhn, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDGFRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Produktdetails anti-PDGFRA Antikörper

Bindungsspezifität: AA 1035-1053

Sequenz: C-GKRNRHSSQT SEESAIETG Remarks: Antigen Modificati on: Amino acids 1035-1053

Spezifität: Recognizes Human PDGF Receptor Type A, doublet, Mr 150/170 kDa.

Kreuzreaktivität (Details): Species reactivity (expected):Chicken, Frog, Mouse, Rat, Zebrafish.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide KLH-conjugated corresponding to amino acids 1035-1053 of Human PDGF.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.2 M Tris-Glycine, pH 7.4 containing 0.12 M Sodium Chloride and 0.05 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze-thaw cycles.

Details zu PDGFRA

Target: PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

Andere Bezeichnung: CD140a / PDGFRA

Hintergrund: Platelet-derived Growth Factor Receptor Alpha (PDGFR alpha), a member of the a PDGF Receptor tyrosine kinase family, is a mediator of the biological actions of platelet-derived growth factor (PDGF). PDGF binding to PDGF receptors result in stimulation of cell growth, chemotaxis, and cell shape changes. Unlike PDGFR beta, PDGFR alpha can bind to both PDGF subunits. PDGFR alpha has been implicated in the development of spina bifida. In various mouse models, deregulated PDGFR alpha expression was found to result in congenital neural tube defects. In humans, various PDGFRA promoter haplotypes have been associated with neural tube defects.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha

Gen-ID: 5156

NCBI Accession: NP_006197

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Platelet-derived growth Factor Receptor Signaling