Cathepsin D Antikörper

Produktnummer ABIN783842

Der Kaninchen Polyklonal anti-Cathepsin D Antikörper wird verwendet zum Nachweis von Cathepsin D in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IP.

Kurzübersicht für Cathepsin D Antikörper (ABIN783842)

Target: Cathepsin D (CTSD)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-Cathepsin D Antikörper

Spezifität: This antibody detects both the 52 kDa proform and the 34 kDa cleaved fragment of Cathepsin D.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide surrounding amino acid 140 of mouse cathepsins D

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS, pH 7.2, 0.01 % Thimerosal, 30 % Glycerol, 0.5 % BSA

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliquots) at -20 to -70 °C.

Details zu Cathepsin D

Target: Cathepsin D (CTSD)

Andere Bezeichnung: Cathepsin D

Hintergrund: Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.Synonyms: CPSD, CTSD

Gen-ID: 1509

NCBI Accession: NP_001900

UniProt: P07339

Pathways: Peptide Hormone Metabolism