Cathepsin D Antikörper
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- Target Alle Cathepsin D (CTSD) Antikörper anzeigen
- Cathepsin D (CTSD)
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Cathepsin D Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP)
- Spezifität
- This antibody detects both the 52 kDa proform and the 34 kDa cleaved fragment of Cathepsin D.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Mouse, Rat.
- Aufreinigung
- Affinity chromatography
- Immunogen
- Synthetic peptide surrounding amino acid 140 of mouse cathepsins D
- Isotyp
- IgG
- Top Product
- Discover our top product CTSD Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- PBS, pH 7.2, 0.01 % Thimerosal, 30 % Glycerol, 0.5 % BSA
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Upon receipt, store (in aliquots) at -20 to -70 °C.
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- Target
- Cathepsin D (CTSD)
- Andere Bezeichnung
- Cathepsin D (CTSD Produkte)
- Synonyme
- catD antikoerper, fb93e11 antikoerper, fj17b09 antikoerper, wu:fb93e11 antikoerper, wu:fj17b09 antikoerper, LOC398557 antikoerper, Cathd antikoerper, CatD antikoerper, LOC100136761 antikoerper, CTSD antikoerper, DKFZp469J0315 antikoerper, DDBDRAFT_0205785 antikoerper, DDBDRAFT_0215012 antikoerper, DDB_0205785 antikoerper, DDB_0215012 antikoerper, CLN10 antikoerper, CPSD antikoerper, CD antikoerper, cathepsin D antikoerper, cathepsin D S homeolog antikoerper, lysosomal aspartic protease antikoerper, cathepsin D-like antikoerper, ctsd antikoerper, LOC398557 antikoerper, ctsd.S antikoerper, CatD antikoerper, LOC5567565 antikoerper, LOC100136761 antikoerper, CTSD antikoerper, Cathd antikoerper, ctsD antikoerper, catd antikoerper, Ctsd antikoerper, LOC443060 antikoerper
- Hintergrund
- Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.Synonyms: CPSD, CTSD
- Gen-ID
- 1509
- NCBI Accession
- NP_001900
- UniProt
- P07339
- Pathways
- Peptide Hormone Metabolism
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