CDC23 Antikörper (Center)

Produktnummer ABIN783825

Dieser Anti-CDC23-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von CDC23 in WB und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CDC23 Antikörper (Center) (ABIN783825)

Target: CDC23 (Cell Division Cycle 23 (CDC23))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC23 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-CDC23 Antikörper

Bindungsspezifität: Center

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human APC8

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu CDC23

Target: CDC23 (Cell Division Cycle 23 (CDC23))

Andere Bezeichnung: CDC23 / APC8

Hintergrund: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.Synonyms: ANAPC8, Anaphase-promoting complex subunit 8, Cell division cycle protein 23 homolog, Cyclosome subunit 8

Gen-ID: 8697

NCBI Accession: NP_004652

UniProt: Q9UJX2

Pathways: Protein targeting to Nucleus