EFCAB4B Antikörper (C-Term)

Produktnummer ABIN783785

Produktdetails anti-EFCAB4B Antikörper

Target: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EFCAB4B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects EFCAB4B at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the carboxy terminus of human EFCAB4B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu EFCAB4B

Target: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Andere Bezeichnung: EFCAB4B (EFCAB4B Produkte)

Synonyme: CRACR2A antikoerper, Gm1073 antikoerper, Gm462 antikoerper, calcium release activated channel regulator 2A antikoerper, CRACR2A antikoerper, Cracr2a antikoerper

Hintergrund: EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.Synonyms: EF-hand calcium-binding domain-containing protein 4B, MGC4266

Gen-ID: 84766

NCBI Accession: NP_001138430

UniProt: Q9BSW2