EFCAB4B Antikörper (N-Term)

Produktnummer ABIN1539404

Produktdetails anti-EFCAB4B Antikörper

Target: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Bindungsspezifität: AA 48-74, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EFCAB4B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EFCAB4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B.

Klon: RB38227

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: EFCAB4B Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu EFCAB4B

Target: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Andere Bezeichnung: EFCAB4B (EFCAB4B Produkte)

Synonyme: CRACR2A antikoerper, Gm1073 antikoerper, Gm462 antikoerper, calcium release activated channel regulator 2A antikoerper, CRACR2A antikoerper, Cracr2a antikoerper

Hintergrund: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Molekulargewicht: 45592

Gen-ID: 84766

NCBI Accession: NP_001138430, NP_116069

UniProt: Q9BSW2