KPNA6 Antikörper (N-Term)
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- Target Alle KPNA6 Antikörper anzeigen
- KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser KPNA6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody detects KPNA6 / Importin alpha-7 at N-term.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, mouse, rat
- Aufreinigung
- Affinity chromatography purified via peptide column
- Immunogen
- 13 amino acid peptide near the amino terminus of human KPNA6
- Top Product
- Discover our top product KPNA6 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS containing 0.02 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- Target
- KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
- Andere Bezeichnung
- KPNA6 / Importin alpha-7 (KPNA6 Produkte)
- Synonyme
- IPOA7 antikoerper, Kpna5 antikoerper, NPI-2 antikoerper, KPNA7 antikoerper, karyopherin subunit alpha 6 antikoerper, karyopherin (importin) alpha 6 antikoerper, karyopherin alpha 6 (importin alpha 7) antikoerper, karyopherin alpha 6 (importin alpha 7) S homeolog antikoerper, KPNA6 antikoerper, Kpna6 antikoerper, kpna6.S antikoerper
- Hintergrund
- Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.Synonyms: IPOA7, KPNA6, Karyopherin subunit alpha-6
- Gen-ID
- 23633
- NCBI Accession
- NP_036448
- UniProt
- O60684
- Pathways
- Protein targeting to Nucleus
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