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KPNA6 Antikörper (N-Term)

KPNA6 Reaktivität: Human, Maus, Ratte WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991418
  • Target Alle KPNA6 Antikörper anzeigen
    KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
    Bindungsspezifität
    • 15
    • 2
    • 2
    • 1
    • 1
    AA 70-120, N-Term
    Reaktivität
    • 23
    • 21
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 22
    • 1
    Kaninchen
    Klonalität
    • 23
    Polyklonal
    Konjugat
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KPNA6 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 13
    • 7
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Aufreinigung
    KPNA6 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    KPNA6 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human KPNA6. The immunogen is located within amino acids 70 - 120 of KPNA6.
    Isotyp
    IgG
    Top Product
    Discover our top product KPNA6 Primärantikörper
  • Applikationshinweise
    KPNA6 antibody can be used for detection of KPNA6 by Western blot at 1 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    KPNA6 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    KPNA6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
    Andere Bezeichnung
    KPNA6 (KPNA6 Produkte)
    Synonyme
    IPOA7 antikoerper, Kpna5 antikoerper, NPI-2 antikoerper, KPNA7 antikoerper, karyopherin subunit alpha 6 antikoerper, karyopherin (importin) alpha 6 antikoerper, karyopherin alpha 6 (importin alpha 7) antikoerper, karyopherin alpha 6 (importin alpha 7) S homeolog antikoerper, KPNA6 antikoerper, Kpna6 antikoerper, kpna6.S antikoerper
    Hintergrund
    KPNA6 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
    Gen-ID
    23633
    UniProt
    O60684
    Pathways
    Protein targeting to Nucleus
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