ATG101 Antikörper (Center)

Produktnummer ABIN783665

Der Kaninchen Polyklonal Anti-ATG101-Antikörper wurde für WB, IHC (p), IF und EIA validiert. Er ist geeignet, ATG101 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ATG101 Antikörper (Center) (ABIN783665)

Target: ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG101 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-ATG101 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody recognizes ATG101 and is predicted to not cross-react with other TG members.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Affinity Chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the center of Human ATG101

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Antibody is supplied in PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ATG101

Target: ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))

Andere Bezeichnung: ATG101

Hintergrund: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG101 is a recently discovered protein that stabilizes ATG13, another autophagy protein that forms a complex with the mammalian homologs of ATG1, ULK1 and ULK2, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions, inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. ATG101 also interacts with ULK1 and is essential for autophagy.Synonyms: Autophagy-related protein 101, C12orf44, PP894, UPF0453 protein C12orf44

Gen-ID: 60673

NCBI Accession: NP_001092143

UniProt: Q9BSB4

Pathways: Autophagie