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NUMB Antikörper (C-Term)
NUMB
Reaktivität: Human, Maus, Ratte
WB, EIA
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-NUMB Antikörper
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Target
Alle NUMB Antikörper anzeigen
NUMB
(Numb Homolog (NUMB))
Bindungsspezifität
Alle Epitope für NUMB Antikörper
C-Term
Reaktivität
Alle Reaktivitäten für NUMB Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für NUMB Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für NUMB Antikörper
Polyklonal
Konjugat
Alle Konjugate für NUMB Antikörper
Dieser NUMB Antikörper ist unkonjugiert
Applikation
Alle Applikationen für NUMB Antikörper
Western Blotting (WB), Enzyme Immunoassay (EIA)
Spezifität
This antibody detects NUMB at C-term. At least four isoforms of NUMB are known to exist, this antibody will detect all of them.
Kreuzreaktivität (Details)
Species reactivity (tested):Human, mouse, rat
Aufreinigung
Affinity chromatography purified via peptide column
Immunogen
17 amino acid peptide near the carboxy terminus of human NUMB
Top Product
Discover our top product NUMB Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Buffer
PBS containing 0.02 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Details zu NUMB
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Target
NUMB
(Numb Homolog (NUMB))
Andere Bezeichnung
NUMB (NUMB Produkte )
Synonyme
C14orf41 antikoerper, S171 antikoerper, c14_5527 antikoerper, Nb antikoerper, NUMB, endocytic adaptor protein antikoerper, numb homolog (Drosophila) antikoerper, NUMB antikoerper, Numb antikoerper, numb antikoerper
Hintergrund
NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells (1,2). NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.Synonyms: Protein S171, Protein numb homolog, h-Numb
Gen-ID
8650
NCBI Accession
NP_001005743
UniProt
P49757
Pathways
Cell-Cell Junction Organization
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