PRR5L Antikörper (Center)

Produktnummer ABIN783444

Dieses Anti-PRR5L-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PRR5L in WB und EIA. Geeignet für Human.

Kurzübersicht für PRR5L Antikörper (Center) (ABIN783444)

Target: PRR5L (Proline Rich 5 Like (PRR5L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRR5L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-PRR5L Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects PRR5L at Center. At least three isoforms of PRR5L are known to exist, this antibody will recognize only isoforms a and b. PRR5L antibody will not cross-react with PPR5.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human PRR5L

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu PRR5L

Target: PRR5L (Proline Rich 5 Like (PRR5L))

Andere Bezeichnung: PRR5L

Hintergrund: Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.Synonyms: FLJ14213, PROTOR2, Proline-rich protein 5-like, Protein observed with Rictor-2

Gen-ID: 79899

NCBI Accession: NP_001153639

UniProt: Q6MZQ0