PRR5L Antikörper (AA 220-270)

Produktnummer ABIN6991524

Der Kaninchen Polyklonal anti-PRR5L Antikörper (ABIN6991524) detektiert spezifisch PRR5L in WB, ELISA, IF und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für PRR5L Antikörper (AA 220-270) (ABIN6991524)

Target: PRR5L (Proline Rich 5 Like (PRR5L))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRR5L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-PRR5L Antikörper

Bindungsspezifität: AA 220-270

Spezifität: At least three isoforms of PRR5L are known to exist, this antibody will recognize only isoforms a and b. PRR5L antibody will not cross-react with PPR5.

Aufreinigung: PRR5L Antibody is affinity chromatography purified via peptide column.

Immunogen: PRR5L antibody was raised against a 17 amino acid synthetic peptide near the center of human PRR5L. The immunogen is located within amino acids 220 - 270 of PRR5L.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PRR5L antibody can be used for detection of PRR5L by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PRR5L Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PRR5L antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PRR5L

Target: PRR5L (Proline Rich 5 Like (PRR5L))

Andere Bezeichnung: PRR5L

Hintergrund: PRR5L Antibody: Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.

Gen-ID: 79899

NCBI Accession: NP_001153639

UniProt: Q6MZQ0