HMMR Antikörper (N-Term)

Produktnummer ABIN783397

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HMMR in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 1 Publikation erwähnt.

Kurzübersicht für HMMR Antikörper (N-Term) (ABIN783397)

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMMR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-HMMR Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects CD168 / HMMR at N-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the amino terminus of human RHAMM

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Referenzen für anti-HMMR Antikörper (ABIN783397)

Li, Ji, Wang: "Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma." in: Neoplasia (New York, N.Y.), Vol. 20, Issue 5, pp. 456-466, (2018) (PubMed).

Details zu HMMR

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Andere Bezeichnung: CD168 / HMMR

Hintergrund: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.Synonyms: Hyaluronan mediated motility receptor, IHABP, Intracellular hyaluronic acid-binding protein, RHAMM, Receptor for hyaluronan-mediated motility

Gen-ID: 3161

NCBI Accession: NP_001136028

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process