LRRTM3 Antikörper (C-Term)

Produktnummer ABIN783383

Der Kaninchen Polyklonal anti-LRRTM3 Antikörper wird verwendet zum Nachweis von LRRTM3 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und EIA.

Kurzübersicht für LRRTM3 Antikörper (C-Term) (ABIN783383)

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRTM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-LRRTM3 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibnody detects LRRTM3 at C-term. At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human LRRTM3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu LRRTM3

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Andere Bezeichnung: LRRTM3

Hintergrund: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the β-secretase BACE, leading to the proteolytic production of the Aβ42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Aβ42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.Synonyms: Leucine-rich repeat transmembrane neuronal protein 3

Gen-ID: 26045

NCBI Accession: NP_056379

UniProt: Q86VH5

Pathways: Synaptic Membrane