LRRTM3 Antikörper (C-Term)

Produktnummer ABIN6991483

Produktdetails anti-LRRTM3 Antikörper

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Bindungsspezifität: C-Term

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRTM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.

Aufreinigung: LRRTM3 Antibody is affinity chromatography purified via peptide column.

Immunogen: LRRTM3 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human LRRTM3. The immunogen is located within the last 50 amino acids of LRRTM3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: LRRTM3 antibody can be used for detection of LRRTM3 by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: LRRTM3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: LRRTM3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu LRRTM3

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Andere Bezeichnung: LRRTM3 (LRRTM3 Produkte)

Synonyme: 9630044H04Rik antikoerper, leucine rich repeat transmembrane neuronal 3 antikoerper, LRRTM3 antikoerper, lrrtm3 antikoerper, Lrrtm3 antikoerper

Hintergrund: LRRTM3 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.

Gen-ID: 347731

NCBI Accession: NP_821079

UniProt: Q86VH5

Pathways: Synaptic Membrane