Progesterone Receptor Antikörper (C-Term)

Produktnummer ABIN781660

Dieser Maus Monoklonal Antikörper detektiert spezifisch Progesterone Receptor in IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human, Kaninchen und Huhn.

Kurzübersicht für Progesterone Receptor Antikörper (C-Term) (ABIN781660)

Target: Progesterone Receptor (PGR)

Reaktivität: Human, Kaninchen, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Progesterone Receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: PR-6A

Produktdetails anti-Progesterone Receptor Antikörper

Bindungsspezifität: AA 922-933, C-Term

Spezifität: This antibody PR-6A recognizes the Human Progesterone Receptor in the C-terminal ligand-binding domain. Therefore, it recognizes isoforms A and B. Antigen Distribution: Nuclear hormone receptor, widely expressed.

Kreuzreaktivität (Details): Species reactivity (expected):Chicken and Rabbit.
Species reactivity (tested):Human, Pig.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide A922-K933. Epitope: C-terminal region.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore by adding 0.5 mL distilled water

Konzentration: 0.2 mg/mL

Buffer: Stock solution contains PBS, pH 7.2 with 5 mg/mL BSA as stabilizer and 0.01 % Kathon as a preservative.

Konservierungsmittel: Kathon CG

Vorsichtsmaßnahmen: This product contains Kathon CG a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Progesterone Receptor

Target: Progesterone Receptor (PGR)

Andere Bezeichnung: Progesterone Receptor

Hintergrund: The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. Expressed by a single gene (chromosome 11q22), it has two main forms, A and B, that differ in their molecular weight. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PR determination provides supplementary information to ER, in predicting response to endocrine therapy as well as estimating survival. PR has proved superior to ER as a prognostic indicator in some studies. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.Synonyms: NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3, PGR, PR

Gen-ID: 5241

NCBI Accession: NP_000917

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration