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CD33 Antikörper (PerCP)

This anti-CD33 antibody (ABIN780369) is a Mouse Monoclonal antibody detecting CD33 in FACS. Suitable for Human, Non-Human Primate.
Produktnummer ABIN780369

Kurzübersicht für CD33 Antikörper (PerCP) (ABIN780369)

Target

Alle CD33 Antikörper anzeigen
CD33

Reaktivität

  • 176
  • 37
  • 16
  • 13
  • 6
  • 6
  • 3
  • 1
Human, Non-Human Primate

Wirt

  • 103
  • 80
  • 3
Maus

Klonalität

  • 96
  • 89
  • 1
Monoklonal

Konjugat

  • 75
  • 15
  • 13
  • 12
  • 10
  • 5
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD33 Antikörper ist konjugiert mit PerCP

Applikation

  • 111
  • 109
  • 46
  • 40
  • 27
  • 26
  • 26
  • 23
  • 19
  • 17
  • 10
  • 8
  • 6
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

WM53
  • Verwendungszweck

    Anti-Hu CD33 PerCP

    Spezifität

    The mouse monoclonal antibody WM53 reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells, it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

    Kreuzreaktivität (Details)

    Human, Non-Human Primates

    Aufreinigung

    Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    Human AML cells

    Isotyp

    IgG1
  • Applikationshinweise

    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    No reconstitution is necessary.

    Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Garnache-Ottou, Chaperot, Biichle, Ferrand, Remy-Martin, Deconinck, de Tailly, Bulabois, Poulet, Kuhlein, Jacob, Salaun, Arock, Drenou, Schillinger, Seilles, Tiberghien, Bensa, Plumas, Saas: "Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells." in: Blood, Vol. 105, Issue 3, pp. 1256-64, (2005) (PubMed).

    Leone, Rutella, Bonanno, Abbate, Rebuzzi, Giovannini, Lombardi, Galiuto, Liuzzo, Andreotti, Lanza, Contemi, Leone, Crea: "Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function." in: European heart journal, Vol. 26, Issue 12, pp. 1196-204, (2005) (PubMed).

    Schenk, Bouchon, Birrer, Colonna, Mueller: "Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 1, pp. 517-24, (2004) (PubMed).

    Vitale, Romagnani, Puccetti, Olive, Costello, Chiossone, Pitto, Bacigalupo, Moretta, Mingari: "Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 10, pp. 5764-9, (2001) (PubMed).

    Shin, Choi, Kim, Chung, Chung, Park, Jung, Kim, Park, Kim, Park, Min, Kim, Park: "Expression of leukemia-associated antigen, JL1, in bone marrow and thymus." in: The American journal of pathology, Vol. 158, Issue 4, pp. 1473-80, (2001) (PubMed).

    Bradstock, Kirk, Grimsley, Kabral, Hughes: "Unusual immunophenotypes in acute leukaemias: incidence and clinical correlations." in: British journal of haematology, Vol. 72, Issue 4, pp. 512-8, (1989) (PubMed).

    Favaloro, Bradstock, Kabral, Grimsley, Zowtyj, Zola et al.: "Further characterization of human myeloid antigens (gp160,95; gp150; gp67): investigation of epitopic heterogeneity and non-haemopoietic distribution using panels of monoclonal antibodies belonging ..." in: British journal of haematology, Vol. 69, Issue 2, pp. 163-71, (1988) (PubMed).

    Favaloro, Bradstock, Kabral, Grimsley, Berndt: "Characterization of monoclonal antibodies to the human myeloid-differentiation antigen, 'gp67' (CD-33)." in: Disease markers, Vol. 5, Issue 4, pp. 215-25, (1988) (PubMed).

  • Target

    CD33

    Andere Bezeichnung

    CD33

    Hintergrund

    CD33 Molecule,CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.,SIGLEC3, p67

    Gen-ID

    945

    UniProt

    P20138
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