MPL Antikörper (pTyr626)

Produktnummer ABIN8123121

Der Kaninchen Polyklonal anti-MPL Antikörper wird verwendet zum Nachweis von MPL in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für MPL Antikörper (pTyr626) (ABIN8123121)

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MPL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MPL Antikörper

Bindungsspezifität: pTyr626

Verwendungszweck: TPOR (Phospho Tyr626) Antibody

Spezifität: This antibody detects endogenous levels of Human TPOR (phospho-Tyr626)

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human TPOR (Tyr626)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MPL

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Andere Bezeichnung: TPOR

Hintergrund:

Synonyms: Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)

Background: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important

Gene Name: MPL TPOR

Protein Name: TPOR (Tyr626)

Gen-ID: 4352

UniProt: P40238

Pathways: JAK-STAT Signalweg