MLKL Antikörper (AA 40-120)

Produktnummer ABIN8123027

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MLKL in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MLKL Antikörper (AA 40-120) (ABIN8123027)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLKL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MLKL Antikörper

Bindungsspezifität: AA 40-120

Verwendungszweck: MLKL Antibody

Spezifität: MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from MLKL . at AA range: 40-120

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000,IHC 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Andere Bezeichnung: MLKL

Hintergrund:

Synonyms: MLKL, Mixed lineage kinase domain-like protein

Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Gene Name: MLKL

Protein Name: Mixed lineage kinase domain-like protein

Gen-ID: 197259

UniProt: Q8NB16