MKNK2 Antikörper (pThr244)

Produktnummer ABIN8122767

Der Kaninchen Polyklonal anti-MKNK2 Antikörper wird verwendet zum Nachweis von MKNK2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für MKNK2 Antikörper (pThr244) (ABIN8122767)

Target: MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MKNK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MKNK2 Antikörper

Bindungsspezifität: pThr244

Verwendungszweck: MNK2 (Phospho Thr244) Antibody

Spezifität: This antibody detects endogenous levels of MNK2 (Phospho-Thr244) at Human, Mouse,Rat

Aufreinigung: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human MNK2 (Phospho-Thr244)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MKNK2

Target: MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Andere Bezeichnung: MNK2

Hintergrund:

Synonyms: MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)

Background: MAP kinase interacting serine/threonine kinase 2(MKNK2) Homo sapiens This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex.

Gene Name: MKNK2 GPRK7 MNK2

Protein Name: MNK2 (Phospho-Thr244)

Gen-ID: 2872

UniProt: Q9HBH9

Pathways: MAPK Signalweg